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Zolpidem tartrate 10 mg for sale in the United States by Pfizer, is available in Europe for the treatment of insomnia and anxiety. Because the drug is relatively Venlafaxine er 75 mg cost new, there has been little research on the safety and efficacy of drug. Furthermore, no information has been published concerning its long-term side-effects. We review the literature regarding effects of this drug on sleep and examine the possibility that these effects may be attributable to a possible genetic polymorphism. METHODS: We searched MEDLINE for studies published up to June 2013 on the effects of diazepam sleep architecture, and evaluated the significance of several possible genetic polymorphisms the 5'-flavin-3'-olipid synthase gene, as it is known to affect sleep. All data were extracted by two independent and blinded reviewers (M.G.N. D.J.B.). All data analyses were conducted using a fixed effects analysis approach, controlling for multiple comparisons and testing the null hypothesis of no differences between the active and placebo groups. RESULTS: Eight articles were found, two by Cochrane and nine the Review Group. articles were published after 2000. The mean number of subjects in the diazepam groups was 32 (range 13-56) in the Cochrane Review Group and 26 (range 12-46) in the Cochrane Review Group. Nineteen studies (42%) assessed diazepam alone. The group had statistically significant greater total sleep time (p = 0.02) and less sleep disruption (p = 0.02) as well less severe insomnia compared to the placebo group. Eight of nine studies (79%) showed a statistically significant reduction in subjective sleepiness (p = 0.03), in total sleep latency (p = 0.02), and in insomnia severity (p<0.001) the diazepam group. Eleven out of 20 studies (56%) showed a statistically significant reduction in the average amount of time in bed per night and an improvement in sleep efficiency as compared to the placebo group. CONCLUSIONS: Long-term generic viagra canadian pharmacy online use of diazepam in adults results a reduction daytime sleepiness, in total sleep time, and improvement in efficiency.
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